The Center of Excellence for the Validation of Digital Health Technologies & Clinical Algorithms prioritizes rigorous external validation of clinical artificial intelligence and machine learning tools to ensure that predictive algorithms, diagnostic models, and decision-support systems perform reliably across varied clinical settings. Recognizing that many AI/ML solutions are often trained on limited or non-representative datasets, the Center emphasizes testing these technologies against real-world, heterogeneous clinical data. Through strategic collaborations and partnerships, the Center advances trustworthy, transparent, and reproducible AI applications that drive meaningful improvements in heart failure, maternal health, oncology, and other critical areas of medicine.